Assistive Communication
For people with locked-in syndrome – the inability to move and to speak despite being fully awake and alert (for example, due to brainstem injury or ALS) – restoration of easy communication is a priority. Our research team is developing technologies that would re-enable the ability to control a cursor on a computer screen or to type on a virtual keyboard, simply by thinking about the movement of one’s own hand (for example, as if controlling a computer mouse).
Related Publications
Jude JJ, Haro S, Levi-Aharoni H, Hashimoto H, Acosta AJ, Card NS, Wairagkar M, Brandman DM, Stavisky SD, Williams ZM, Cash SS, Simeral JD, Hochberg LR, Rubin DB.
Decoding intended speech with an intracortical brain-computer interface in a person with longstanding anarthria and locked-in syndrome
[Preprint]. bioRxiv. 2025 Aug 12: [24 p.]. doi: 10.1101/2025.08.12.668516
Jude JJ, Levi-Aharoni H, Acosta AJ, Allcroft SB, Nicolas C, Lacayo BE, Card NS, Wairagkar M, Levin AD, Brandman DM, Stavisky SD, Willett FR, Williams ZM, Simeral JD, Hochberg LR, Rubin DB.
Restoring rapid natural bimanual typing with a neuroprosthesis after paralysis
Nat Neurosci. 2026 Mar 16. doi: 10.1038/s41593-026-02218-y. Epub ahead of print. PMID: 41840138.
Nicholas S. Card, Maitreyee Wairagkar, Carrina Iacobacci, Xianda Hou, Tyler Singer-Clark, Francis R. Willett, Erin M. Kunz, Chaofei Fan, Maryam Vahdati Nia, Darrel R. Deo, Aparna Srinivasan, Eun Young Choi, Matthew F. Glasser, Leigh R. Hochberg, Jaimie M. Henderson, Kiarash Shahlaie, Sergey D. Stavisky, and David M. Brandman
An Accurate and Rapidly Calibrating Speech Neuroprosthesis
N Engl J Med 14 Aug 2024; 391 (7) DOI: 10.1056/NEJMoa2314132







