The potential to restore function after paralysis is only one potential benefit of harnessing the power of intracortical signals. Our research team is also exploring the use of these information-rich neural signals to better understand and treat other neurological disorders and diseases, such as epilepsy. We hypothesize that the unprecedented level of detail enabled by recording ensembles of single neurons (10s-100s of neurons) not only will allow us to study how seizures start, but will also lead to the generation of warning signals and the creation of next-generation devices that can reduce or stop seizures. We are testing this hypothesis with the help of patients with seizures who are already scheduled for pre-surgical recordings for epilepsy management. This work is contributing to a radical rethinking of how seizures start and stop and is focused on yielding new treatments for epilepsy.
Park YS, Cosgrove GR, Madsen JR, Eskandar EN, Hochberg LR, Cash SS, Truccolo W.
IEEE Trans Biomed Eng. 2020 Mar;67(3):817-831. doi: 10.1109/TBME.2019.2921448. Epub 2019 Jun 6.
Proix T, Aghagolzadeh M, Madsen JR, Cosgrove R, Eskandar EE, Hochberg LR, Cash SS, Truccolo W.
PLoS One. 2019 Jul 22;14(7):e0211847. doi: 10.1371/journal.pone.0211847. eCollection 2019.
Aghagolzadeh M, Hochberg LR, Cash SS, Truccolo W.
Annu Int Conf IEEE Eng Med Biol Soc. 2016 Aug;2016:6353-6356. doi: 10.1109/EMBC.2016.7592181.