Our Publications

Shah NP, Willsey MS, Hahn N, Kamdar F, Avansino DT, Fan C, Hochberg LR, Willett FR, Henderson JM.

A flexible intracortical brain-computer interface for typing using finger movements.

bioRxiv 26 Apr 2024 DOI: 10.1101/2024.04.22.590630

Ali YH, Bodkin K, Rigotti-Thompson M, Patel K, Card NS, Bhaduri B, Nason-Tomaszewski SR, Mifsud DM, Hou X, Nicolas C, Allcroft S, Hochberg LR, Au Yong N, Stavisky SD, Miller LE, Brandman DM, Pandarinath C.

BRAND: a platform for closed-loop experiments with deep network models.

J Neural Eng 17 Apr 2024; 21 (2) DOI: 10.1088/1741-2552/ad3b3a

Card NS, Wairagkar M, Iacobacci C, Hou X, Singer-Clark T, Willett FR, Kunz EM, Fan C, Nia MV, Deo DR, Srinivasan A, Choi EY, Glasser MF, Hochberg LR, Henderson JM, Shahlaie K, Brandman DM, Stavisky SD.

An accurate and rapidly calibrating speech neuroprosthesis.

medRxiv 10 Apr 2024; DOI: 10.1101/2023.12.26.23300110

Orellana V D, Donoghue JP, Vargas-Irwin CE.

Low frequency independent components: Internal neuromarkers linking cortical LFPs to behavior.

iScience 16 Feb 2024; 27 (2): 108310. DOI: 10.1016/j.isci.2023.108310

Deo DR, Willet FR, Avansino DT, Hochberg LR, Henderson JM, Shenoy KV

Brain control of bimanual movement enabled by recurrent neural networks

Scientific Reports 18 January 2024; DOI: 10.1038/s41598-024-51617-3

Verzhbinsky IA, Rubin DB, Kajfez S, Bu Y, Kelemen JN, Kapitonava A, Williams ZM, Hochberg LR, Cash SS, Halgren E.

Co-occurring ripple oscillations facilitate neuronal interactions between cortical locations in humans.

Proc Natl Acad Sci USA 02 Jan 2024; 121 (1): e2312204121. DOI: 10.1073/pnas.2312204121

Willett FR, Kunz EM, Fan C, Avansino DT, Wilson GH, Choi EY, Kamdar F, Glasser MF, Hochberg LR, Druckmann S, Shenoy KV, Henderson JM

A high-performance speech neuroprosthesis

Nature 23 August 2023; DOI: 10.1038/s41586-023-06377-x. Epub ahead of print.

Hosman T*, Pun TK*, Kapitonava A, Simeral JD†, Hochberg LR†

Months-long high-performance fixed LSTM decoder for cursor control in human intracortical brain-computer interfaces

2023 11th International IEEE/EMBS Conference on Neural Engineering (NER), Baltimore, MD, USA. 2023 May. pp. 1-5, doi: 10.1109/NER52421.2023.10123740.

Rubin DB, Ajiboye AB, Barefoot L, Bowker M, Cash SS, Chen D, Donoghue JP, Eskandar EN, Friehs G, Grant C, Henderson JM, Kirsch RF, Marujo R, Masood M, Mernoff S, Miller JP, Mukand JA, Penn RD, Shefner J, Shenoy KV, Simeral JD, Sweet JA, Walter BL, Williams ZM, Hochberg LR.

Interim Safety Profile from the Feasibility Study of the BrainGate Neural Interface System

Neurology 13 January 2023; DOI: 10.1212/WNL.0000000000201707. Epub ahead of print.

Rubin DB, Hosman T, Kelemen JN, Kapitonava A, Willett FR, Coughlin BF, Halgren E, Kimchi EY, Williams ZM, Simeral JD, Hochberg LR, Cash SS.

Learned motor patterns are replayed in human motor cortex during sleep

Journal of Neuroscience 22 June 2022, 42 (25) 5007-5020; DOI: https://doi.org/10.1523/JNEUROSCI.2074-21.2022

Willett FR, Avansino DT, Hochberg LR, Henderson JM, Shenoy KV.

High-performance brain-to-text communication via handwriting

Nature. 2021 May 12; 593: 249–54. doi: 10.1038/s41586-021-03506-2. Prior version as submitted to bioRxiv.

Deo DR, Rezaii P, Hochberg LR, Okamura A, Shenoy KV, Henderson JM.

Effects of Peripheral Haptic Feedback on Intracortical Brain-Computer Interface Control and Associated Sensory Responses in Motor Cortex.

IEEE Trans Haptics. 2021 Apr 12;PP. doi: 10.1109/TOH.2021.3072615. Epub ahead of print.

Young MJ, Lin DJ, Hochberg LR.

Brain-Computer Interfaces in Neurorecovery and Neurorehabilitation

Seminars in Neurology. 2021 Apr;41(2):206-216. doi: 10.1055/s-0041-1725137.

Simeral JD, Hosman T, Saab J, Flesher SN, Vilela M, Franco B, Kelemen J, Brandman DM, Ciancibello JG, Rezaii PG, Eskandar EN, Rosler DM, Shenoy KV, Henderson JM, Nurmikko AV, Hochberg LR.

Home Use of a Percutaneous Wireless Intracortical Brain-Computer Interface by Individuals With Tetraplegia.

IEEE Trans Biomed Eng. 2021 Mar 30;PP. doi: 10.1109/TBME.2021.3069119.

Rastogi A, Willett FR, Abreu J, Crowder DC, Murphy BA, Memberg WD, Vargas-Irwin CE, Miller JP, Sweet J, Walter BL, Rezaii PG, Stavisky SD, Hochberg LR, Shenoy KV, Henderson JM, Kirsch RF, Ajiboye AB.

The Neural Representation of Force across Grasp Types in Motor Cortex of Humans with Tetraplegia.

eNeuro. 2021 Feb 19;8(1):ENEURO.0231-20.2020. doi: 10.1523/ENEURO.0231-20.2020.

Hosman T, Hynes JB, Saab J, Wilcoxen KG, Buchbinder BR, Schmansky N, Cash SS, Eskandar EN, Simeral JD, Franco B, Kelemen J, Vargas-Irwin CE, Hochberg LR.

Auditory cues reveal intended movement information in middle frontal gyrus neuronal ensemble activity of a person with tetraplegia.

Scientific Reports. 2021 Jan11;11(98). doi: 10.1038/s41598-020-77616-8.

Wilson GH, Stavisky SD, Willett FR, Avansino DT, Kelemen JN, Hochberg LR, Henderson JM, Druckmann S, Shenoy KV.

Decoding spoken English from intracortical electrode arrays in dorsal precentral gyrus.

J Neural Eng. 2020 Nov 11;17(6). doi: 0.1088/1741-2552/abbfef.

Even-Chen N, Muratore DG, Stavisky SD, Hochberg LR, Henderson JM, Murmann B, Shenoy K.

Power-saving design opportunities for wireless intracortical brain–computer interfaces.

Nat Biomed Eng. 2020 Aug 3.

Burkhart MC, Brandman DM, Franco B, Hochberg LR, Harrison MT.

The Discriminative Kalman Filter for Bayesian Filtering with Nonlinear and Nongaussian Observation Models.

Neural Comput. 2020 May;32(5):969-1017. doi: 10.1162/neco_a_01275. Epub 2020 Mar 18.PMID: 32187000.

Eichenlaub JB*, Jarosiewicz B*, Saab J, Franco B, Kelemen J, Halgren E, Hochberg LR, Cash SS.

Replay of learned neural firing sequences during rest in human motor cortex.

Cell Reports. 2020 May 5;31:107581.

Willett FR, Deo DR, Avansino DT, Rezaii P, Hochberg LR, Henderson JM, Shenoy KV.

Hand Knob Area of Premotor Cortex Represents the Whole Body in a Compositional Way.

Cell. 2020 Apr 16;181(2):396-409.e26. doi: 10.1016/j.cell.2020.02.043. Epub 2020 Mar 26.PMID: 32220308

Park YS, Cosgrove GR, Madsen JR, Eskandar EN, Hochberg LR, Cash SS, Truccolo W.

Early Detection of Human Epileptic Seizures Based on Intracortical Microelectrode Array Signals.

IEEE Trans Biomed Eng. 2020 Mar;67(3):817-831. doi: 10.1109/TBME.2019.2921448. Epub 2019 Jun 6.

Vilela M, Hochberg LR.

Applications of brain-computer interfaces to the control of robotic and prosthetic arms.

Handb Clin Neurol. 2020 Mar;168:87-99. doi: 10.1016/B978-0-444-63934-9.00008-1.PMID: 32164870

Stavisky SD, Willett FR, Avansino DT, Hochberg LR, Shenoy KV, Henderson JM.

Speech-related dorsal motor cortex activity does not interfere with iBCI cursor control.

J Neural Eng. 2020 Feb 5;17(1):016049. doi: 10.1088/1741-2552/ab5b72.PMID: 32023225.

Rastogi A, Vargas-Irwin CE, Willett FR, Abreu J, Crowder DC, Murphy BA, Memberg WD, Miller JP, Sweet JA, Walter BL, Cash SS, Rezaii PG, Franco B, Saab J, Stavisky SD, Shenoy KV, Henderson JM,Hochberg LR, Kirsch RF, Ajiboye AB.

Neural Representation of Observed, Imagined, and Attempted Grasping Force in Motor Cortex of Individuals with Chronic Tetraplegia.

Sci Rep. 2020 Jan 29;10(1):1429. doi: 10.1038/s41598-020-58097-1.PMID: 31996696.

Stavisky SD, Willett FR, Wilson GH, Murphy BA, Rezaii P, Avansino DT, Memberg WD, Miller JP, Kirsch RF, Hochberg LR, Ajiboye AB, Druckmann S, Shenoy KV, Henderson JM.

Neural ensemble dynamics in dorsal motor cortex during speech in people with paralysis.

eLife. 2019 Dec 10;8:e46015.

Milekovic T, Bacher D, Sarma AA, Simeral JD, Saab J, Pandarinath C, Yvert B, Sorice BL, Blabe C, Oakley EM, Tringale KR, Eskandar E, Cash SS, Shenoy KV*, Jaimie M. Henderson*, Hochberg LR, Donoghue JP.

Volitional control of single-electrode high gamma local field potentials by people with paralysis.

Journal of Neurophysiology. 2019 Apr 11; 121(4): 1428-1450.

Hosman T, Vilela M, Milstein D, Kelemen JN, Brandman DM, Hochberg LR, Simeral JD.

BCI decoder performance comparison of an LSTM recurrent neural network and a Kalman filter in retrospective simulation.

2019 9th International IEEE/EMBS Conference on Neural Engineering (NER), San Francisco, CA, USA. 2019 Mar. pp. 1066-1071.

Proix T, Aghagolzadeh M, Madsen JR, Cosgrove R, Eskandar EE, Hochberg LR, Cash SS, Truccolo W.

Intracortical neural activity distal to seizure-onset-areas predicts human focal seizures.

PLoS One. 2019 Jul 22;14(7):e0211847. doi: 10.1371/journal.pone.0211847. eCollection 2019.

Willett FR, Young DR, Murphy BA, Memberg WD, Blabe CH, Pandarinath C, Stavisky SD, Rezaii P, Saab J, Walter BL, Sweet JA.

Principled BCI Decoder Design and Parameter Selection Using a Feedback Control Model

Scientific reports. 2019 Jun 20;9(1):8881. doi: 10.1038/s41598-019-44166-7.

Young D, Willett F, Memberg WD, Murphy B, Rezaii P, Walter B, Sweet J, Miller J, Shenoy KV, Hochberg LR, Kirsch RF, Ajiboye AB.

Closed-loop cortical control of virtual reach and posture using Cartesian and joint velocity commands

J Neural Eng. 2019 Jan 29;16(2):026011. doi: 10.1088/1741-2552/aaf606.

Nuyujukian P, Albites Sanabria J, Saab J, Pandarinath C, Jarosiewicz B, Blabe CH, Franco B, Mernoff ST, Eskandar EN, Simeral JD, Hochberg LR, Shenoy KV, Henderson JM.

Cortical control of a tablet computer by people with paralysis.

PLoS ONE. 2018 Nov 21; 13(11).

Vargas-Irwin CE, Feldman JM, King B, Simeral JD, Sorice BL, Oakley EM, Cash SS, Eskandar EN, Friehs GM, Hochberg LR, Donoghue JP.

Watch, Imagine, Attempt: Motor Cortex Single-Unit Activity Reveals Context-Dependent Movement Encoding in Humans With Tetraplegia.

Front Hum Neurosci. 2018 Nov 15;12. doi.org/10.3389/fnhum.2018.00450.

Stavisky SD, Kao JC, Nuyujukian P, Pandarinath C, Blabe C, Ryu SI, Hochberg LR, Henderson JM, Shenoy KV.

Brain-machine interface cursor position only weakly affects monkey and human motor cortical activity in the absence of arm movements

Scientific Reports. 2018 Nov 5;8(1):16357. doi: 10.1038/s41598-018-34711-1.

Brandman DM, Burkhart MC, Kelemen J, Franco B, Harrison MT, Hochberg LR.

Robust Closed-Loop Control of a Cursor in a Person with Tetraplegia using Gaussian Process Regression.

Neural Computation. 2018 Nov;30(11):2986-3008.

Pandarinath C, O'Shea DJ, Collins J, Jozefowicz R, Stavisky SD, Kao JC, Trautmann EM, Kaufman MT, Ryu SI, Hochberg LR, Henderson JM, Shenoy KV, Abbott LF, Sussillo D.

Inferring single-trial neural population dynamics using sequential auto-encoders.

Nature Methods. 2018.

Even-Chen N, Stavisky SD, Pandarinath C, Nuyujukian P, Blabe CH, Hochberg LR, Henderson JM, Shenoy KV.

Feasibility of Automatic Error Detect-and-Undo System in Human Intracortical Brain-Computer Interfaces

IEEE Trans Biomed Eng. 2018 Aug;65(8):1771-1784. doi: 10.1109/TBME.2017.2776204.

Young D, Willett F, Memberg WD, Murphy B, Walter B, Sweet J, Miller J, Hochberg LR, Kirsch RF, Ajiboye AB.

Signal processing methods for reducing artifacts in microelectrode brain recordings caused by functional electrical stimulation.

J Neural Eng. 2018 Apr;15(2). Epub 2017 Dec 4.

Milekovic T*, Sarma AA*, Bacher D, Simeral JD, Saab J, Pandarinath C, Sorice BL, Blabe C, Oakley EM, Tringale KR, Eskandar E, Cash SS, Henderson JM, Shenoy KV, Donoghue JP, Hochberg LR.

Stable long-term BCI-enabled communication in ALS and locked-in syndrome using LFP signals.

J. Neurophysiol. 2018 Apr 25;120(1).

Brandman DM, Hosman T, Saab J, Burkhart M, Shanahan B, Ciancibello J, Sarma AA, Milstein DJ, Vargas-Irwin C, Franco B, Kelemen JN, Blabe CH, Murphy BA, Young DR, Willett FR, Pandarinath C, Stavisky SD, Kirsch RF, Walter BL, Ajiboye AB, Cash SS, Eskandar EN, Miller JP, Sweet JA, Shenoy KV, Henderson JM, Jarosiewicz B, Harrison MT, Simeral JD, Hochberg LR.

Rapid calibration of an intracortical brain computer interface for people with tetraplegia.

J. Neural Eng. 2018 Jan 24.

Willett FR, Murphy BA, Young DR, Memberg WD, Blabe CH, Pandarinath C, Franco B, Saab J, Walter BL, Sweet JA, Miller JP, Henderson JM, Shenoy KV, Simeral JD, Jarosiewicz B, Hochberg LR, Kirsch RF, Ajiboye AB.

A comparison of intention estimation methods for decoder calibration in intracortical brain-computer interfaces.

IEEE Eng Med Biol Soc. 2017 Dec 14. doi: 10.1109/TBME.2017.2783358.

Milstein DJ, Pacheco JL, Hochberg LR, Simeral JD, Jarosiewicz B, Sudderth EB.

Multiscale semi-Markov dynamics for intracortical brain-computer interfaces.

31st Conference on Neural Information Processing Systems (NIPS). 2017 Dec.

Jarosiewicz B, Sarma AA, Saab J, Franco B, Cash SS, Eskandar EN, Hochberg LR.

Retrospectively supervised click decoder calibration for self-calibrating point-and-click brain-computer interfaces.

J Physiol Paris. 2017 Mar 8. pii: S0928-4257(17)30010-4. doi: 10.1016/j.jphysparis.2017.03.001. [Epub ahead of print].

Brandman DM, Cash SS, Hochberg LR.

Review: Human Intracortical recording and neural decoding for brain-computer interfaces.

IEEE Trans Neural Syst Rehabil Eng. 2017 Mar 2. doi: 10.1109/TNSRE.2017.2677443. [Epub ahead of print].

Ajiboye AB, Willett FR, Young DR, Memberg WD, Murphy BA, Miller JP, Walter BL, Sweet JA, Hoyen HA, Keith MW, Peckham PH, Simeral JD, Donoghue JP, Hochberg LR, Kirsch RF.

Restoration of reaching and grasping movements through brain-controlled muscle stimulation in a person with tetraplegia: a proof-of-concept demonstration

The Lancet. 2017 Mar 28.

Pandarinath C, Nuyujukian P, Blabe CH, Sorice BL, Saab J, Willett FR, Hochberg LR, Shenoy KV, Henderson JM.

High performance communication by people with paralysis using an intracortical brain-computer interface.

eLife 2017;6:e18554.

Willett FR, Murphy BA, Memberg WD, Blabe CH, Pandarinath C, Walter BL, Sweet JA, Miller JP, Henderson JM, Shenoy KV, Hochberg LR, Kirsch RF, Ajiboye AB.

Signal-independent noise in intracortical brain-computer interfaces causes movement time properties inconsistent with Fitts’ law.

J Neural Eng. 2017 Feb 8;14(2):026010. doi: 10.1088/1741-2552/aa5990. [Epub ahead of print].

Willett FR, Pandarinath C, Jarosiewicz B, Murphy BA, Memberg WD, Blabe CH, Saab J, Walter BL, Sweet JA, Miller JP, Henderson JM, Shenoy KV, Simeral JD, Hochberg LR, Kirsch RF, Ajiboye AB.

Feedback control policies employed by people using intracortical brain-computer interfaces.

J Neural Eng. 2016 Nov 30;14(1):016001. [Epub ahead of print].

Aghagolzadeh M, Hochberg LR, Cash SS, Truccolo W.

Predicting seizures from local field potentials recorded via intracortical microelectrode arrays.

Annu Int Conf IEEE Eng Med Biol Soc. 2016 Aug;2016:6353-6356. doi: 10.1109/EMBC.2016.7592181.

Wagner FB, Eskandar EN, Cosgrove GR, Madsen JR, Blum AS, Potter NS, Hochberg LR, Cash SS, Truccolo W.

Microscale spatiotemporal dynamics during neocortical propagation of human focal seizures.

Neuroimage. 2015 Nov 15;122:114-30. doi: 10.1016/j.neuroimage.2015.08.019. Epub 2015 Aug 14.

Jarosiewicz B, Sarma AA, Bacher D, Masse NY, Simeral JD, Sorice B, Oakley EM, Blabe C, Pandarinath C, Gilja V, Cash SS, Eskandar EN, Friehs G, Henderson JM, Shenoy KV, Donoghue JP, Hochberg LR.

Virtual typing by people with tetraplegia using a self-calibrating intracortical brain-computer interface.

Sci Transl Med. 2015 Nov 11;7(313):313ra179. doi: 10.1126/scitranslmed.aac7328.

Gilja V*, Pandarinath C*, Blabe CH, Nuyujukian P, Simeral JD, Sarma AA, Sorice BL, Perge JA, Jarosiewicz B, Hochberg LR, Shenoy KV, Henderson JM.

Clinical translation of a high-performance neural prosthesis.

Nat Med. 2015 Oct;21(10):1142-5. doi: 10.1038/nm.3953. Epub 2015 Sep 28.

Pandarinath C, Gilja V, Blabe CH, Nuyujukian P, Sarma AA, Sorice BL, Eskandar EN, Hochberg LR, Henderson JM, Shenoy KV.

Neural population dynamics in human motor cortex during movements in people with ALS.

eLife. 2015; 4: e07436.

Bacher D, Jarosiewicz B, Masse NY, Stavisky SD, Simeral JD, Newell K, Oakley EM, Cash SS, Friehs G, Hochberg LR.

Neural Point-and-Click Communication by a Person With Incomplete Locked-In Syndrome.

Neurorehabil Neural Repair. 2015 Jun;29(5):462-71. doi: 10.1177/1545968314554624. Epub 2014 Nov 10.

Cash SS, Hochberg LR.

The emergence of single neurons in clinical neurology

Neuron. 2015 Apr 8;86(1):79-91. doi: 10.1016/j.neuron.2015.03.058.

Malik WQ, Hochberg LR, Donoghue JP, Brown EN

Modulation depth estimation and variable selection in state-space models for neural interfaces.

IEEE Trans Biomed Eng. 2015 Feb;62(2):570-81. Epub 2014 Sep 26.

Yin M, Borton DA, Komar J, Agha N, Lu Y, Li H, Laurens J, Lang Y, Li Q, Bull C, Larson L, Rosler D, Bezard E, Courtine G, Nurmikko AV.

Wireless neurosensor for full-spectrum electrophysiology recordings during free behavior.

Neuron. 2014 Dec 17;84(6):1170-82. doi: 10.1016/j.neuron.2014.11.010. Epub 2014 Dec 4.

Masse NY, Jarosiewicz B, Simeral JD, Bacher D, Stavisky SD, Cash SS, Oakley EM, Berhanu E, Eskandar E, Friehs G, Hochberg LR, Donoghue JP.

Non-causal spike filtering improves decoding of movement intention for intracortical BCIs.

J Neurosci Methods. 2014 Oct 30;236:58-67. Epub 2014 Aug 13.

Chan AM, Dykstra AR, Jayaram V, Leonard MK, Travis KE, Gygi B, Baker JM, Eskandar E, Hochberg LR, Halgren E, Cash SS

Speech-specific tuning of neurons in human superior temporal gyrus

Cerebral Cortex. 2014 Oct 1;24(10):2679-93. doi: 10.1093/cercor/bht127

Perge JA, Zhang S, Malik WQ, Homer ML, Cash S, Friehs G, Eskandar EN, Donoghue JP, Hochberg LR.

Reliability of directional information in unsorted spikes and local field potentials recorded in human motor cortex.

J Neural Eng. 2014 Aug;11(4):046007. Epub 2014 Jun 12.

Truccolo W, Ahmed OJ, Harrison MT, Eskandar EN, Cosgrove GR, Madsen JR, Blum AS, Potter NS, Hochberg LR, Cash SS.

Neuronal ensemble synchrony during human focal seizures.

J Neurosci. 2014 Jul 23;34(30):9927-44.

Homer ML, Perge JA, Black MJ, Harrison MT, Cash SS, Hochberg LR.

Adaptive offset correction for intracortical brain-computer interfaces

IEEE Trans Neural Syst Rehabil Eng. 2014 Mar;22(2):239-48. doi: 10.1109/TNSRE.2013.2287768.

Park YS, Hochberg LR, Eskandar EN, Cash SS, Truccolo W.

Early detection of human focal seizures based on cortical multiunit activity.

Proc IEEE Eng Med Biol Soc. 2014; 2014:5796-9.

Jarosiewicz B, Masse NY, Bacher D, Cash SS, Eskandar E, Friehs G, Donoghue JP, and Hochberg LR.

Advantages of closed-loop calibration in intracortical brain-computer interfaces for people with tetraplegia.

J Neural Eng. 2013 Aug;10(4):046012. Epub 2013 Jul 10.

Perge JA, Homer ML, Malik WQ, Cash S, Eskandar E, Friehs G, Donoghue JP, and Hochberg LR.

Intra-day signal instabilities affect decoding performance in an intracortical neural interface system.

J Neural Eng. 2013 Jun;10(3):036004. Epub 2013 Apr 10.

Shaikhouni A, Donoghue JP, and Hochberg LR.

Somatosensory responses in a human motor cortex.

J Neurophysiol. 2013 Apr;109(8):2192-204. Epub 2013 Jan 23.

Borton DA, Yin M, Aceros J, Nurmikko A.

An implantable wireless neural interface for recording cortical circuit dynamics in moving primates.

J Neural Eng. 2013 Apr;10(2):026010. doi: 10.1088/1741-2560/10/2/026010. Epub 2013 Feb 21.

Yin M, Borton DA, Aceros J, Patterson WR, Nurmikko AV.

A 100-channel hermetically sealed implantable device for chronic wireless neurosensing applications.

IEEE Trans Biomed Circuits Syst. 2013 Apr;7(2):115-28.

Homer ML, Nurmikko AV, Donoghue JP, and Hochberg LR.

Sensors and decoding for intracortical brain computer interfaces.

Annu Rev Biomed Eng. 2013;15:383-405.

Ajiboye AB, Simeral JD, Donoghue JP, Hochberg LR, and Kirsch RF.

Prediction of imagined single-joint movements in a person with high-level tetraplegia.

IEEE Trans Biomed Eng. 2012 Oct;59(10):2755-65. Epub 2012 Jul 23.

Hochberg LR, Bacher D, Jarosiewicz B, Masse NY, Simeral JD, Vogel J, Haddadin S, Liu J, van der Smagt P, Donoghue JP.

Reach and grasp by people with tetraplegia using a neurally controlled robotic arm.

Nature. 2012 May 17; 485 (7398): 372-5.

Truccolo W, Donoghue JA, Hochberg LR, Eskandar EN, Madsen JR, Anderson WS, Brown EN, Halgren E, and Cash SS.

Single-neuron dynamics in human focal epilepsy.

Nature Neuroscience. 2011 May;14(5):635-41. Epub 2011 Mar 27. • Editorial: The ups and downs of seizure activity

Chadwick EK, Blana D, Simeral JD, Lambrecht J, Kim SP, Cornwell AS, Taylor DM, Hochberg LR, Donoghue JP, Kirsch RF.

Continuous neuronal ensemble control of simulated arm reaching by a human with tetraplegia

J Neural Eng. 2011 Jun;8(3):034003. doi: 10.1088/1741-2560/8/3/034003. Epub 2011 May 5.

Kim SP, Simeral JD, Hochberg LR, Donoghue JP, Friehs GM, and Black MJ.

Point-and-click cursor control with an intracortical neural interface system by humans with tetraplegia.

IEEE Trans Neural Sys Rehabil Eng. 2011, Apr; 19(2): 193-203.

Simeral JD, Kim SP, Black MJ, Donoghue JP, and Hochberg LR.

Neural control of cursor trajectory and click by a human with tetraplegia 1000 days after implant of an intracortical microelectrode array.

Journal of Neural Engineering 2011. 8(2) 025027.

Malik WQ, Truccolo W, Brown EN, and Hochberg LR.

Efficient Decoding With Steady-State Kalman Filter in Neural Interface Systems.

IEEE Transaction on Neural Systems and Rehabilitation Engineering. 2011 Feb; 19(1):25-34. Epub 2010 Nov 15.

Keller CJ, Truccolo W, Gale JT, Eskandar E, Thesen T, Carlson C, Devinsky O, Kuzniecky R, Doyle WK, Madsen JR, Schomer DL, Mehta AD, Brown EN, Hochberg LR, Ulbert I, Halgren E, and Cash SS.

Heterogeneous neuronal firing patterns during interictal epileptiform discharges in the human cortex.

Brain 2010 Apr 17 133: 1668-1681.

Zhuang J, Truccolo W, Vargas-Irwin C, and Donoghue JP (2010 Apr 15).

Decoding 3-D Reach and Grasp Kinematics from High-Frequency Local Field Potentials in Primate Primary Motor Cortex.

IEEE Transactions on Biomedical Engineering.

Nurmikko AV, Donoghue JP, Hochberg LR, Patterson WR, Song YK, Bull CW, Borton DA, Laiwalla F, Park S, Ming Y, and Aceros J (2010 Feb 25).

Listening to Brain Microcircuits for Interfacing With External World—Progress in Wireless Implantable Microelectronic Neuroengineering Devices.

Proc IEEE. 98:3. 375-388.

Truccolo, W.

Stochastic models for multivariate neural point processes: collective dynamics and neural decoding.

in Analysis of Parallel Spike Trains (eds. Grün, S. & Rotter, S.), Springer, New York, 2010

Truccolo W, Hochberg LR, and Donoghue JP.

Collective dynamics in human and monkey sensorimotor cortex: Predicting single neuron spikes.

Nature Neuroscience 2009 Dec 6 (Epub ahead of print).

Song YK, Borton DA, Park S, Patterson WR, Bull CW, Laiwalla F, Mislow J, Simeral JD, Donoghue JP, and Nurmikko AV.

Active microelectronic neurosensor arrays for implantable brain communication interfaces.

IEEE Trans Neural Syst Rehabil Eng. 2009 Aug;17(4):339-45. Epub 2009 Jun 5.

Hatsopoulos, NG and Donoghue JP.

The Science of Neural Interface Systems.

Annu Rev Neurosci. 2009;32:249-66.

Kim SP, Simeral J, Hochberg LR, Donoghue JP, and Black MJ.

Neural control of computer cursor velocity by decoding motor cortical spiking activity in humans with tetraplegia.

J. Neural Engin. 2008 (Dec) 5: 455-476.

Donoghue JP.

Bridging the brain to the world: a perspective on neural interface systems.

Neuron. 2008 Nov 6;60(3):511-21.

Hochberg LR.

Turning thought into action.

N.Engl.J.Med. 2008 Sep 11; 359(11): 1175-7.

Truccolo W, Friehs GM, Donoghue JP, and Hochberg LR.

Primary motor cortex tuning to intended movement kinematics in humans with tetraplegia.

J.Neuroscience 2008 Jan 30; 28(5): 1163-78.

Kim SP, Simeral JD, Hochberg LR, Donoghue JP, Friehs GM, and Black MJ.

Multi-state decoding of point-and-click control signals from motor cortical activity in a human with tetraplegia.

3rd International IEEE-EMBS Conference 2007 May:486-489.

Donoghue JP, Nurmikko A, Black M, and Hochberg LR.

Assistive technology and robotic control using motor cortex ensemble-based neural interface systems in humans with tetraplegia.

J Physiol. 2007 Mar 15; 579 (Pt 3): 603-11.

Truccolo, W. and Donoghue JP.

Nonparametric modeling of neural point processes via stochastic gradient boosting regression.

Neural Computation. 2007 19 (3): 672-705.

Hochberg LR and Taylor DM.

Intuitive prosthetic limb control.

Lancet. 2007 Feb 3; 369 (9559): 345-6.

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