Our Publications

Wilson GH, Stavisky SD, Willett FR, Avansino DT, Kelemen JN, Hochberg LR, Henderson JM, Druckmann S, Shenoy KV.

Decoding spoken English from intracortical electrode arrays in dorsal precentral gyrus

J Neural Eng. 2020 Nov 11;17(6). doi: 0.1088/1741-2552/abbfef.

Even-Chen N, Muratore DG, Stavisky SD, Hochberg LR, Henderson JM, Murmann B, Shenoy K.

Power-saving design opportunities for wireless intracortical brain–computer interfaces.

Nat Biomed Eng. 2020 Aug 3.

Burkhart MC, Brandman DM, Franco B, Hochberg LR, Harrison MT.

The Discriminative Kalman Filter for Bayesian Filtering with Nonlinear and Nongaussian Observation Models.

Neural Comput. 2020 May;32(5):969-1017. doi: 10.1162/neco_a_01275. Epub 2020 Mar 18.PMID: 32187000

Eichenlaub JB*, Jarosiewicz B*, Saab J, Franco B, Kelemen J, Halgren E, Hochberg LR, Cash SS.

Replay of learned neural firing sequences during rest in human motor cortex.

Cell Reports. 2020 May 5;31:107581.

Willett FR, Deo DR, Avansino DT, Rezaii P, Hochberg LR, Henderson JM, Shenoy KV.

Hand Knob Area of Premotor Cortex Represents the Whole Body in a Compositional Way.

Cell. 2020 Apr 16;181(2):396-409.e26. doi: 10.1016/j.cell.2020.02.043. Epub 2020 Mar 26.PMID: 32220308

Willett FR*, Deo DR*, Avansino DT, Rezaii Paymon, Hochberg LR, Henderson JM**, Shenoy KV**

Hand knob area of motor cortex in people with tetraplegia represents the whole body in a compositional way.

Cell. 2020 Mar 26;181:1–14.

Vilela M, Hochberg LR.

Applications of brain-computer interfaces to the control of robotic and prosthetic arms.

Handb Clin Neurol. 2020 Mar;168:87-99. doi: 10.1016/B978-0-444-63934-9.00008-1.PMID: 32164870

Stavisky SD, Willett FR, Avansino DT, Hochberg LR, Shenoy KV, Henderson JM.

Speech-related dorsal motor cortex activity does not interfere with iBCI cursor control.

J Neural Eng. 2020 Feb 5;17(1):016049. doi: 10.1088/1741-2552/ab5b72.PMID: 32023225

Rastogi A, Vargas-Irwin CE, Willett FR, Abreu J, Crowder DC, Murphy BA, Memberg WD, Miller JP, Sweet JA, Walter BL, Cash SS, Rezaii PG, Franco B, Saab J, Stavisky SD, Shenoy KV, Henderson JM,Hochberg LR, Kirsch RF, Ajiboye AB.

Neural Representation of Observed, Imagined, and Attempted Grasping Force in Motor Cortex of Individuals with Chronic Tetraplegia.

Sci Rep. 2020 Jan 29;10(1):1429. doi: 10.1038/s41598-020-58097-1.PMID: 31996696

Stavisky SD, Willett FR, Wilson GH, Murphy BA, Rezaii P, Avansino DT, Memberg WD, Miller JP, Kirsch RF, Hochberg LR, Ajiboye AB, Druckmann S, Shenoy KV, Henderson JM.

Neural ensemble dynamics in dorsal motor cortex during speech in people with paralysis.

eLife. 2019 Dec 10;8:e46015.

Milekovic T, Bacher D, Sarma AA, Simeral JD, Saab J, Pandarinath C, Yvert B, Sorice BL, Blabe C, Oakley EM, Tringale KR, Eskandar E, Cash SS, Shenoy KV*, Jaimie M. Henderson*, Hochberg LR, Donoghue JP

Volitional control of single-electrode high gamma local field potentials by people with paralysis.

Journal of Neurophysiology. 2019 Apr 11; 121(4): 1428-1450.

Hosman T, Vilela M, Milstein D, Kelemen JN, Brandman DM, Hochberg LR, Simeral JD.

BCI decoder performance comparison of an LSTM recurrent neural network and a Kalman filter in retrospective simulation.

2019 9th International IEEE/EMBS Conference on Neural Engineering (NER), San Francisco, CA, USA. 2019 Mar. pp. 1066-1071.

Nuyujukian P, Albites Sanabria J, Saab J, Pandarinath C, Jarosiewicz B, Blabe CH, Franco B, Mernoff ST, Eskandar EN, Simeral JD, Hochberg LR, Shenoy KV, Henderson JM.

Cortical control of a tablet computer by people with paralysis

PLoS ONE. 2018 Nov 21; 13(11).

Vargas-Irwin CE, Feldman JM, King B, Simeral JD, Sorice BL, Oakley EM, Cash SS, Eskandar EN, Friehs GM, Hochberg LR, Donoghue JP.

Watch, Imagine, Attempt: Motor Cortex Single-Unit Activity Reveals Context-Dependent Movement Encoding in Humans With Tetraplegia

Front Hum Neurosci. 2018 Nov 15;12. doi.org/10.3389/fnhum.2018.00450

Brandman DM, Burkhart MC, Kelemen J, Franco B, Harrison MT, Hochberg LR.

Robust Closed-Loop Control of a Cursor in a Person with Tetraplegia using Gaussian Process Regression.

Neural Computation. 2018 Nov;30(11):2986-3008

Pandarinath C, O'Shea DJ, Collins J, Jozefowicz R, Stavisky SD, Kao JC, Trautmann EM, Kaufman MT, Ryu SI, Hochberg LR, Henderson JM, Shenoy KV, Abbott LF, Sussillo D.

Inferring single-trial neural population dynamics using sequential auto-encoders.

Nature Methods. 2018.

Young D, Willett F, Memberg WD, Murphy B, Walter B, Sweet J, Miller J, Hochberg LR, Kirsch RF, Ajiboye AB.

Signal processing methods for reducing artifacts in microelectrode brain recordings caused by functional electrical stimulation.

J Neural Eng. 2018 Apr;15(2)

Milekovic T*, Sarma AA*, Bacher D, Simeral JD, Saab J, Pandarinath C, Sorice BL, Blabe C, Oakley EM, Tringale KR, Eskandar E, Cash SS, Henderson JM, Shenoy KV, Donoghue JP, Hochberg LR.

Stable long-term BCI-enabled communication in ALS and locked-in syndrome using LFP signals.

J. Neurophysiol. 2018 Apr 25;120(1).

Brandman DM, Hosman T, Saab J, Burkhart M, Shanahan B, Ciancibello J, Sarma AA, Milstein DJ, Vargas-Irwin C, Franco B, Kelemen JN, Blabe CH, Murphy BA, Young DR, Willett FR, Pandarinath C, Stavisky SD, Kirsch RF, Walter BL, Ajiboye AB, Cash SS, Eskandar EN, Miller JP, Sweet JA, Shenoy KV, Henderson JM, Jarosiewicz B, Harrison MT, Simeral JD, Hochberg LR

Rapid calibration of an intracortical brain computer interface for people with tetraplegia.

J. Neural Eng. 2018 Jan 24.

Willett FR, Murphy BA, Young DR, Memberg WD, Blabe CH, Pandarinath C, Franco B, Saab J, Walter BL, Sweet JA, Miller JP, Henderson JM, Shenoy KV, Simeral JD, Jarosiewicz B, Hochberg LR, Kirsch RF, Ajiboye AB.

A comparison of intention estimation methods for decoder calibration in intracortical brain-computer interfaces.

IEEE Eng Med Biol Soc. 2017 Dec 14. doi: 10.1109/TBME.2017.2783358

Milstein DJ, Pacheco JL, Hochberg LR, Simeral JD, Jarosiewicz B, Sudderth EB

Multiscale semi-Markov dynamics for intracortical brain-computer interfaces.

31st Conference on Neural Information Processing Systems (NIPS). 2017 Dec.

Young D, Willett F, Memberg WD, Murphy B, Walter B, Sweet JA, Miller J, Hochberg L, Kirsch RF, Ajiboye AB.

Signal processing methods for reducing artifacts in microelectrode brain recordings caused by functional electrical stimulation.

J. Neural Eng. 2017 Dec 4. doi: 10.1088/1741-2552/aa9ee8. [Epub ahead of print]

Jarosiewicz B, Sarma AA, Saab J, Franco B, Cash SS, Eskandar EN, Hochberg LR.

Retrospectively supervised click decoder calibration for self-calibrating point-and-click brain-computer interfaces.

J Physiol Paris. 2017 Mar 8. pii: S0928-4257(17)30010-4. doi: 10.1016/j.jphysparis.2017.03.001. [Epub ahead of print]

Brandman DM, Cash SS, Hochberg LR.

Review: Human Intracortical recording and neural decoding for brain-computer interfaces.

IEEE Trans Neural Syst Rehabil Eng. 2017 Mar 2. doi: 10.1109/TNSRE.2017.2677443. [Epub ahead of print]

Ajiboye AB, Willett FR, Young DR, Memberg WD, Murphy BA, Miller JP, Walter BL, Sweet JA, Hoyen HA, Keith MW, Peckham PH, Simeral JD, Donoghue JP, Hochberg LR, Kirsch RF

Restoration of reaching and grasping movements through brain-controlled muscle stimulation in a person with tetraplegia: a proof-of-concept demonstration

The Lancet. 2017 Mar 28.

Pandarinath C, Nuyujukian P, Blabe CH, Sorice BL, Saab J, Willett FR, Hochberg LR, Shenoy KV, Henderson JM.

High performance communication by people with paralysis using an intracortical brain-computer interface.

eLife 2017;6:e18554.

Willett FR, Murphy BA, Memberg WD, Blabe CH, Pandarinath C, Walter BL, Sweet JA, Miller JP, Henderson JM, Shenoy KV, Hochberg LR, Kirsch RF, Ajiboye AB.

Signal-independent noise in intracortical brain-computer interfaces causes movement time properties inconsistent with Fitts’ law.

J Neural Eng. 2017 Feb 8;14(2):026010. doi: 10.1088/1741-2552/aa5990. [Epub ahead of print]

Willett FR, Pandarinath C, Jarosiewicz B, Murphy BA, Memberg WD, Blabe CH, Saab J, Walter BL, Sweet JA, Miller JP, Henderson JM, Shenoy KV, Simeral JD, Hochberg LR, Kirsch RF, Ajiboye AB.

Feedback control policies employed by people using intracortical brain-computer interfaces.

J Neural Eng. 2016 Nov 30;14(1):016001. [Epub ahead of print]

Jarosiewicz B, Sarma AA, Bacher D, Masse NY, Simeral JD, Sorice B, Oakley EM, Blabe C, Pandarinath C, Gilja V, Cash SS, Eskandar EN, Friehs G, Henderson JM, Shenoy KV, Donoghue JP, Hochberg LR

Virtual typing by people with tetraplegia using a self-calibrating intracortical brain-computer interface

Sci Transl Med. 2015 Nov 11;7(313):313ra179. doi: 10.1126/scitranslmed.aac7328.

Gilja V*, Pandarinath C*, Blabe CH, Nuyujukian P, Simeral JD, Sarma AA, Sorice BL, Perge JA, Jarosiewicz B, Hochberg LR, Shenoy KV, Henderson JM.

Clinical translation of a high-performance neural prosthesis.

Nat Med. 2015 Oct;21(10):1142-5. doi: 10.1038/nm.3953. Epub 2015 Sep 28.

Pandarinath C, Gilja V, Blabe CH, Nuyujukian P, Sarma AA, Sorice BL, Eskandar EN, Hochberg LR, Henderson JM, Shenoy KV

Neural population dynamics in human motor cortex during movements in people with ALS.

eLife. 2015; 4: e07436.

Bacher D, Jarosiewicz B, Masse NY, Stavisky SD, Simeral JD, Newell K, Oakley EM, Cash SS, Friehs G, Hochberg LR

Neural Point-and-Click Communication by a Person With Incomplete Locked-In Syndrome.

Neurorehabil Neural Repair. 2015 Jun;29(5):462-71. doi: 10.1177/1545968314554624. Epub 2014 Nov 10.

Malik WQ, Hochberg LR, Donoghue JP, Brown EN

Modulation depth estimation and variable selection in state-space models for neural interfaces.

IEEE Trans Biomed Eng. 2015 Feb;62(2):570-81. Epub 2014 Sep 26.

Yin M, Borton DA, Komar J, Agha N, Lu Y, Li H, Laurens J, Lang Y, Li Q, Bull C, Larson L, Rosler D, Bezard E, Courtine G, Nurmikko AV.

Wireless neurosensor for full-spectrum electrophysiology recordings during free behavior.

Neuron. 2014 Dec 17;84(6):1170-82. doi: 10.1016/j.neuron.2014.11.010. Epub 2014 Dec 4.

Masse NY, Jarosiewicz B, Simeral JD, Bacher D, Stavisky SD, Cash SS, Oakley EM, Berhanu E, Eskandar E, Friehs G, Hochberg LR, Donoghue JP

Non-causal spike filtering improves decoding of movement intention for intracortical BCIs.

J Neurosci Methods. 2014 Oct 30;236:58-67. Epub 2014 Aug 13.

Perge JA, Zhang S, Malik WQ, Homer ML, Cash S, Friehs G, Eskandar EN, Donoghue JP, Hochberg LR

Reliability of directional information in unsorted spikes and local field potentials recorded in human motor cortex.

J Neural Eng. 2014 Aug;11(4):046007. Epub 2014 Jun 12.

Truccolo W, Ahmed OJ, Harrison MT, Eskandar EN, Cosgrove GR, Madsen JR, Blum AS, Potter NS, Hochberg LR, Cash SS

Neuronal ensemble synchrony during human focal seizures.

J Neurosci. 2014 Jul 23;34(30):9927-44.

Park YS, Hochberg LR, Eskandar EN, Cash SS, Truccolo W.

Early detection of human focal seizures based on cortical multiunit activity.

Proc IEEE Eng Med Biol Soc. 2014; 2014:5796-9.

Jarosiewicz B, Masse NY, Bacher D, Cash SS, Eskandar E, Friehs G, Donoghue JP, and Hochberg LR

Advantages of closed-loop calibration in intracortical brain-computer interfaces for people with tetraplegia.

J Neural Eng. 2013 Aug;10(4):046012. Epub 2013 Jul 10.

Perge JA, Homer ML, Malik WQ, Cash S, Eskandar E, Friehs G, Donoghue JP, and Hochberg LR

Intra-day signal instabilities affect decoding performance in an intracortical neural interface system.

J Neural Eng. 2013 Jun;10(3):036004. Epub 2013 Apr 10.

Shaikhouni A, Donoghue JP, and Hochberg LR

Somatosensory responses in a human motor cortex.

J Neurophysiol. 2013 Apr;109(8):2192-204. Epub 2013 Jan 23.

Borton DA, Yin M, Aceros J, Nurmikko A.

An implantable wireless neural interface for recording cortical circuit dynamics in moving primates.

J Neural Eng. 2013 Apr;10(2):026010. doi: 10.1088/1741-2560/10/2/026010. Epub 2013 Feb 21.

Yin M, Borton DA, Aceros J, Patterson WR, Nurmikko AV.

A 100-channel hermetically sealed implantable device for chronic wireless neurosensing applications.

IEEE Trans Biomed Circuits Syst. 2013 Apr;7(2):115-28.

Homer ML, Nurmikko AV, Donoghue JP, and Hochberg LR

Sensors and decoding for intracortical brain computer interfaces.

Annu Rev Biomed Eng. 2013;15:383-405.

Ajiboye AB, Simeral JD, Donoghue JP, Hochberg LR, and Kirsch RF

Prediction of imagined single-joint movements in a person with high-level tetraplegia.

IEEE Trans Biomed Eng. 2012 Oct;59(10):2755-65. Epub 2012 Jul 23.

Hochberg LR, Bacher D, Jarosiewicz B, Masse NY, Simeral JD, Vogel J, Haddadin S, Liu J, van der Smagt P, Donoghue JP

Reach and grasp by people with tetraplegia using a neurally controlled robotic arm.

Nature. 2012 May 17; 485 (7398): 372-5.

Truccolo W, Donoghue JA, Hochberg LR, Eskandar EN, Madsen JR, Anderson WS, Brown EN, Halgren E, and Cash SS

Single-neuron dynamics in human focal epilepsy

Nature Neuroscience. 2011 May;14(5):635-41. Epub 2011 Mar 27. • Editorial: The ups and downs of seizure activity

Kim SP, Simeral JD, Hochberg LR, Donoghue JP, Friehs GM, and Black MJ

Point-and-click cursor control with an intracortical neural interface system by humans with tetraplegia.

IEEE Trans Neural Sys Rehabil Eng. 2011, Apr; 19(2): 193-203.

Simeral JD, Kim SP, Black MJ, Donoghue JP, and Hochberg LR

Neural control of cursor trajectory and click by a human with tetraplegia 1000 days after implant of an intracortical microelectrode array

Journal of Neural Engineering 2011. 8(2) 025027.

Malik WQ, Truccolo W, Brown EN, and Hochberg LR

Efficient Decoding With Steady-State Kalman Filter in Neural Interface Systems

IEEE Transaction on Neural Systems and Rehabilitation Engineering. 2011 Feb; 19(1):25-34. Epub 2010 Nov 15.

Keller CJ, Truccolo W, Gale JT, Eskandar E, Thesen T, Carlson C, Devinsky O, Kuzniecky R, Doyle WK, Madsen JR, Schomer DL, Mehta AD, Brown EN, Hochberg LR, Ulbert I, Halgren E, and Cash SS

Heterogeneous neuronal firing patterns during interictal epileptiform discharges in the human cortex

Brain 2010 Apr 17 133: 1668-1681

Zhuang J, Truccolo W, Vargas-Irwin C, and Donoghue JP (2010 Apr 15).

Decoding 3-D Reach and Grasp Kinematics from High-Frequency Local Field Potentials in Primate Primary Motor Cortex.

IEEE Transactions on Biomedical Engineering.

Nurmikko AV, Donoghue JP, Hochberg LR, Patterson WR, Song YK, Bull CW, Borton DA, Laiwalla F, Park S, Ming Y, and Aceros J (2010 Feb 25)

Listening to Brain Microcircuits for Interfacing With External World—Progress in Wireless Implantable Microelectronic Neuroengineering Devices.

Proc IEEE. 98:3. 375-388.

Truccolo, W.

Stochastic models for multivariate neural point processes: collective dynamics and neural decoding.

in Analysis of Parallel Spike Trains (eds. Grün, S. & Rotter, S.), Springer, New York, 2010

Truccolo W, Hochberg LR, and Donoghue JP

Collective dynamics in human and monkey sensorimotor cortex: Predicting single neuron spikes.

Nature Neuroscience 2009 Dec 6 (Epub ahead of print)

Song YK, Borton DA, Park S, Patterson WR, Bull CW, Laiwalla F, Mislow J, Simeral JD, Donoghue JP, and Nurmikko AV

Active microelectronic neurosensor arrays for implantable brain communication interfaces.

IEEE Trans Neural Syst Rehabil Eng. 2009 Aug;17(4):339-45. Epub 2009 Jun 5.

Hatsopoulos, NG and Donoghue JP

The Science of Neural Interface Systems.

Annu Rev Neurosci. 2009;32:249-66.

Kim SP, Simeral J, Hochberg LR, Donoghue JP, and Black MJ

Neural control of computer cursor velocity by decoding motor cortical spiking activity in humans with tetraplegia.

J. Neural Engin. 2008 (Dec) 5: 455-476

Donoghue JP

Bridging the brain to the world: a perspective on neural interface systems.

Neuron. 2008 Nov 6;60(3):511-21.

Hochberg LR

Turning thought into action.

N.Engl.J.Med. 2008 Sep 11; 359(11): 1175-7

Truccolo W, Friehs GM, Donoghue JP, and Hochberg LR

Primary motor cortex tuning to intended movement kinematics in humans with tetraplegia.

J.Neuroscience 2008 Jan 30; 28(5): 1163-78

Kim SP, Simeral JD, Hochberg LR, Donoghue JP, Friehs GM, and Black MJ

Multi-state decoding of point-and-click control signals from motor cortical activity in a human with tetraplegia

3rd International IEEE-EMBS Conference 2007 May:486-489

Donoghue JP, Nurmikko A, Black M, and Hochberg LR

Assistive technology and robotic control using motor cortex ensemble-based neural interface systems in humans with tetraplegia.

J Physiol. 2007 Mar 15; 579 (Pt 3): 603-11

Truccolo, W. and Donoghue JP

Nonparametric modeling of neural point processes via stochastic gradient boosting regression.

Neural Computation. 2007 19 (3): 672-705

Hochberg LR and Taylor DM

Intuitive prosthetic limb control.

Lancet. 2007 Feb 3; 369 (9559): 345-6

Song YK, Patterson WR, Bull CW, Borton DA, Li Y, Nurmikko AV, Simeral JD, and Donoghue JP

A brain implantable microsystem with hybrid RF/IR telemetry for advanced neuroengineering applications.

Conf Proc IEEE Eng. Med Biol. Soc. 2007: 445-8

Donoghue JP, Hochberg LR, Nurmikko AV, Black MJ, Simeral JD, and Friehs G.

Neuromotor prosthesis development.

Med Health R I. 2007 Jan ; 90 (1): 12-5

Aaron RK, Herr HM, Ciombor DM, Hochberg LR, Donoghue JP, Briant CL, Morgan JR, and Ehrlich, MG

Horizons in prosthesis development for the restoration of limb function.

J Am Acad Orthop Surg. 2006 Oct ; 14 (10 Suppl): S198-204

Hochberg LR and Donoghue JP

Sensors for brain-computer interfaces.

IEEE Eng Med Biol Mag. 2006 ; 25 (5): 32-8

Hochberg LR, Serruya MD, Friehs GM, Mukand JA, Saleh M, Caplan AH, Branner A, Chen D, Penn RD, and Donoghue JP

Neuronal ensemble control of prosthetic devices by a human with tetraplegia.

Nature. 2006 Jul 13; 442 (7099): 164-71

Kübler A, Mushahwar VK, Hochberg LR, and Donoghue JP

BCI Meeting 2005–workshop on clinical issues and applications.

IEEE Trans Neural Syst Rehabil Eng. 2006 Jun ; 14 (2): 131-4

Truccolo W, Eden UT, Fellows MR, Donoghue JP, and Brown EN

A Point Process Framework for Relating Neural Spiking Activity to Spiking History, Neural Ensemble and Extrinsic Covariate Effects.

Journal of Neurophysiology 93, 1074-1089. 2005.

Eden UT, Truccolo W, Fellows MR, Donoghue JP, and Brown EN

Reconstruction of Hand Movement Trajectories from a Dynamic Ensemble of Spiking Motor Cortical Neurons.

Proceedings of the 26th Annual International Conference of the IEEE EMBS, San Francisco, CA. 2004.

Serruya M, Hatsopoulos N, Fellows M, Paninski L, and Donoghue J

Robustness of neuroprosthetic decoding algorithms.

Biol Cybern. 2003 Mar;88(3):219-28.

Serruya MD, Hatsopoulos NG, Paninski L, Fellows MR, and Donoghue JP

Instant neural control of a movement signal.

Nature. 2002 Mar 14;416(6877):141-2.

Burrow M, Dugger J, Humphrey DR, Reed DJ, and Hochberg LR

Cortical control of a robot using a time-delay neural network

International Conference on Rehabilitation Robotics, 1997.

Humphrey, DR and Hochberg LR

Intracortical Recording Of Brain Activity For Control Of Limb Prostheses

Proceedings of the Rehabilitation Engineering Society of North America, 1995.