Movement Restoration
For people with cervical spinal cord injury or brainstem stroke, signals from the motor cortex have been “disconnected” from the limb. We are seeking to reunite these signals via brain-computer interface (BCI)-driven muscle activation. Intra-cortical implants pick up electrical neural activity in the brain and send that information to a computer, where the signals associated with intended movements are decoded. The computer then sends electrical impulses to muscles via implanted stimulating electrodes, which induce limb movement.
One of the goals of implanted neural interfaces is to provide natural, intuitive, real-time control of assistive devices that would be helpful to people with paralysis or limb loss. Recent work has markedly advanced the field of prosthetics for people who have had one or both arms amputated due to trauma or vascular disease. Additionally, there are safe and useful robotic limbs that can be attached to a wheelchair and used much in the same way the arm and hand was used prior to injury to the nervous system. We are working to evaluate the feasibility of using the brain signals directly related to intended movement of the hand to enable easier and more complex control over these advanced prosthetic limbs and assistive robotic devices.
Related Publications
Shah NP, Willsey MS, Hahn N, Kamdar F, Avansino DT, Fan C, Hochberg LR, Willett FR, Henderson JM.
A flexible intracortical brain-computer interface for typing using finger movements.
bioRxiv 26 Apr 2024 DOI: 10.1101/2024.04.22.590630
Deo DR, Willet FR, Avansino DT, Hochberg LR, Henderson JM, Shenoy KV
Brain control of bimanual movement enabled by recurrent neural networks
Scientific Reports 18 January 2024; DOI: 10.1038/s41598-024-51617-3
Rastogi A, Willett FR, Abreu J, Crowder DC, Murphy BA, Memberg WD, Vargas-Irwin CE, Miller JP, Sweet J, Walter BL, Rezaii PG, Stavisky SD, Hochberg LR, Shenoy KV, Henderson JM, Kirsch RF, Ajiboye AB.
The Neural Representation of Force across Grasp Types in Motor Cortex of Humans with Tetraplegia.
eNeuro. 2021 Feb 19;8(1):ENEURO.0231-20.2020. doi: 10.1523/ENEURO.0231-20.2020.