Speech Restoration
Losing the ability to speak is often one of the most disabling symptoms of neurologic disease. For people with ALS, brainstem stroke, and other related conditions, the cortical areas that control language and speech are intact but cannot transmit their signals to the motor structures that produce speech. Through research discovering the neural signals responsible for speech production, and by utilizing cutting-edge machine learning techniques to generate advanced decoding algorithms, our research team is developing a system to restore fluent communication for people that have lost the ability to speak. As we learn how to decode intended speech directly from the cortex, signals will be paired with text-generating or synthetic speech-generating devices to restore fluent conversational speech for people affected by neurologic injury or disease.
Related Publications
Srinivasan A, Wairagkar M, Iacobacci C, Hou X, Card NS, Jacques BG, Pritchard AL, Bechefsky PH, Hochberg LR, AuYong N, Pandarinath C, Brandman DM, Stavisky SD
Encoding of speech modes and loudness in ventral precentral gyrus
Nat Commun. 2026 Apr 15. doi: 10.1038/s41467-026-71284-4. PMID: 41986329.
Jude JJ, Haro S, Levi-Aharoni H, Hashimoto H, Acosta AJ, Card NS, Wairagkar M, Brandman DM, Stavisky SD, Williams ZM, Cash SS, Simeral JD, Hochberg LR, Rubin DB.
Decoding intended speech with an intracortical brain-computer interface in a person with long-standing anarthria and locked-in syndrome
Cell Rep. 2026 Mar 30;45(4):117162. doi: 10.1016/j.celrep.2026.117162. Epub ahead of print. PMID: 41920737.
Hou X, Iacobacci C, Card NS, Wairagkar M, Singer-Clark T, Kunz EM, Fan C, Kamdar F, Hahn N, Hochberg LR, Henderson JM, Willett FR, Brandman DM, Stavisky SD.
Error encoding in human speech motor cortex
bioRxiv [Preprint]. 2025 Jun 8:2025.06.07.658426. doi: 10.1101/2025.06.07.658426. PMID: 40661574; PMCID: PMC12259010.







